Nano Archive

Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Sousa, Fernanda and Mandal, Subhra and Garrovo, Chiara and Astolfo, Alberto and Bonifacio, Alois and Latawiec, Diane and Menk, Ralf Hendrik and Arfelli, Fulvia and Huewel, Sabine and Legname, Giuseppe and Galla, Hans-Joachim and Krol, Silke (2010) Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study. Nanoscale .

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Abstract

In the present study, the in vivo distribution of polyelectrolyte multilayer coated gold nanoparticles is shown, starting from the living animal down to cellular level. The coating was designed with functional moieties to serve as a potential nano drug for prion disease. With near infrared time-domain imaging we followed the biodistribution in mice up to 7 days after intravenous injection of the nanoparticles. The peak concentration in the head of mice was detected between 19 and 24 h. The precise particle distribution in the brain was studied ex vivo by X-ray microtomography, confocal laser and fluorescence microscopy. We found that the particles mainly accumulate in the hippocampus, thalamus, hypothalamus, and the cerebral cortex.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
ID Code:9963
Deposited By:CSMNT
Deposited On:28 Nov 2010 15:01
Last Modified:28 Nov 2010 15:01

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