Sun, Min and Gao, Yan and Guo, Chenyu and Cao, Fengliang and Song, Zhimei and Xi, Yanwei and Yu, Aihua and Li, Aiguo and Zhai, Guangxi (2010) Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle. Journal of Nanoparticle Research, 12 (8). pp. 3111-3122.
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Curcumin, a widely used coloring agent and spice in food, has a potential in blocking brain tumor formation and curing Alzheimer’s disease. Due to the speciﬁc properties of blood–brain barrier (BBB), only traces of curcumin were transported across BBB. The aim of the present study was to design and characterize curcumin loaded poly-butylcyanoacrylate nanoparticles (PBCN) coated with polysorbate 80, and to evaluate the effect of PBCN as a delivery system on carrying curcumin across BBB. Curcumin loaded nanoparticles were prepared by an anionic polymerization method, and they presented in a core–shell spherical shape under transmission electron microscopy, with an average diameter of 152.0 nm. The average drug loading was 21.1%. Physicochemical status of curcumin in the nanoparticles was conﬁrmed with differential scan-ning colorimetry and Fourier transform infrared spectroscopy. The in vitro release behavior of drug from the nanoparticles was ﬁtted to a double phase kinetics model. The studies of pharmacokinetic and bio-distribution to brain were conducted in mice after intravenous administration of the nanoparticle for-mulation at the dose of 5 mg/kg and curcumin solution at the dose of 10 mg/kg via the tail vein. The results showed that in plasma, the area under concentration–time curve (AUC0–?) for curcumin loaded nanoparticles was greater than that for the control solution, moreover, the mean residence time of curcumin loaded nanoparticles was 14-fold that of the control solution. In brain, AUC0–? for curcumin loaded nanoparticles was 2.53-fold that for the control solution. In conclusion, the present study demonstrated that PBCN could enhance the transport of curcumin to brain and have a potential as a delivery system to cross the BBB.
|Subjects:||Material Science > Nanochemistry|
|Deposited On:||14 Jan 2011 06:51|
|Last Modified:||14 Jan 2011 06:51|
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