Nano Archive

Handheld impedance biosensor system using engineered proteinaceous receptors

Ghafar-Zadeh, Ebrahim and Chowdhury, Shafinaz F. and Aliakbar, Amir and Chodavarapu, Vamsy and Lambrose, Rosemond and Beital, Lenord and Sawan, Mohamad and Trifiro, Mark (2010) Handheld impedance biosensor system using engineered proteinaceous receptors. Biomedical Microdevices, 12 (6). pp. 967-975.

[img]
Preview
PDF
668Kb

Official URL: http://www.springerlink.com/content/657hq13p460l88...

Abstract

We put forward an impedometric protein-based biosensor platform suitable for point-of-care diagnostics. A hand-held scale impedance reader system is described for the detection of corresponding physiochemical changes as the immobilized proteins bind to the analyte molecules in the proximity of the microfabricated electrodes. Specifically, we study the viability of this approach for glucose biosensing purposes using genetically engineered glucokinase as receptor proteins. The proposed reagent-less biosensor offers a high sensitivity of 0.5 mM glucose concentration level in the physiologically relevant range of 0.5 mM to 7.5 mM with less than 10 s response time.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Physics
Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:9895
Deposited By:JNCASR
Deposited On:26 Nov 2010 05:41
Last Modified:26 Nov 2010 05:41

Repository Staff Only: item control page