Nano Archive

One-step synthesis of chitosan-silica hybrid microspheres in a microfluidic device

Lan, Wenjie and Li, Shaowei and Xu, Jianhong and Luo, Guangsheng (2010) One-step synthesis of chitosan-silica hybrid microspheres in a microfluidic device. Biomedical Microdevices, 12 (6). pp. 1087-1095.

[img]
Preview
PDF
789Kb

Official URL: http://www.springerlink.com/content/w70301062t5763...

Abstract

This article describes a simple microfluidic method to fabricate chitosan-silica hybrid microspheres in one step. We dissolved tetraethoxysilane (TEOS) into a chitosan/acetic acid aqueous solution to form a chitosan-silica sol, and then emulsified it in an organic phase mainly containing n-octanol and an organic base triotylamine (TOA) via a co-axial microfluidic device. The formed aqueous droplets were solidified because of the extraction of acetic acid and water to the organic phase. The simple method presented has the advantages of controllable sphere diameter, narrow size distribution and good sphericity. The porous structures of the microspheres were displayed by SEM images. It is found that the inner and surface structures can be controlled by adjusting the solidification reagent component. Furthermore, we chemically grafted bovine serum albumin (BSA) on the microspheres. The existence of silica in the chitosan spheres can enhance both of mechanical intensity and protein loading capacity of the microspheres.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Physics
Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:9883
Deposited By:JNCASR
Deposited On:26 Nov 2010 05:41
Last Modified:26 Nov 2010 05:41

Repository Staff Only: item control page