Nano Archive

Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies

Almeida, Juliana S. and Lima, Fernanda and Ros, Simoni and Bulhoes, Luis O. S. and Carvalho, Leandro M. and Beck, Ruy C. R. (2010) Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies. Nanoscale Research Letters, 5 (10). pp. 1603-1610.

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The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 +/- A 2.06 and 124.17 +/- A 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical center dot OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 +/- A 0.6) 10(-3) and (5.1 +/- A 0.4) 10(-3) for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 +/- A 3.7) 10(-3) min(-1)] and exposed solution [(40.1 +/- A 1.7) 10(-3) min(-1)] as well as compared to exposed nanostructured dispersions [(19.5 +/- A 0.5) 10(-3) and (26.6 +/- A 2.6) 10(-3), for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutin-loaded nanostructures represent alternatives to the development of innovative nanomedicines.

Item Type:Article
Subjects:Material Science > Nanostructured materials
ID Code:9862
Deposited By:CSMNT
Deposited On:28 Dec 2010 13:16
Last Modified:28 Dec 2010 13:16

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