Almeida, Juliana S. and Lima, Fernanda and Ros, Simoni and Bulhoes, Luis O. S. and Carvalho, Leandro M. and Beck, Ruy C. R. (2010) Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies. Nanoscale Research Letters, 5 (10). pp. 1603-1610.
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The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 +/- A 2.06 and 124.17 +/- A 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical center dot OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 +/- A 0.6) 10(-3) and (5.1 +/- A 0.4) 10(-3) for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 +/- A 3.7) 10(-3) min(-1)] and exposed solution [(40.1 +/- A 1.7) 10(-3) min(-1)] as well as compared to exposed nanostructured dispersions [(19.5 +/- A 0.5) 10(-3) and (26.6 +/- A 2.6) 10(-3), for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutin-loaded nanostructures represent alternatives to the development of innovative nanomedicines.
|Subjects:||Material Science > Nanostructured materials|
|Deposited On:||28 Dec 2010 13:16|
|Last Modified:||28 Dec 2010 13:16|
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