Nano Archive

Radiolabelling of TiO2 nanoparticles for radiotracer studies

Abbas, Kamel and Cydzik, Izabela and Torchio, Riccardo and Farina, Massimo and Forti, Efrat and Gibson, Neil and Holzwarth, Uwe and Simonelli, Federica and Kreyling, Wolfgang (2010) Radiolabelling of TiO2 nanoparticles for radiotracer studies. Journal of Nanoparticle Research, 12 (7). pp. 2435-2443.

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Abstract

Industrially manufactured titanium dioxide nanoparticles have been successfully radiolabelled with 48V by irradiation with a cyclotron-generated proton beam. Centrifugation tests showed that the 48V radiolabels were stably bound within the nanoparticle structure in an aqueous medium, while X-ray diffraction indicated that no major structural modifications to the nanoparticles resulted from the proton irradiation. In vitro tests of the uptake of cold and radiolabelled nanoparticles using the human cell line Calu-3 showed no significant difference in the uptake between both batches of nanoparticles. The uptake was quantified by Inductively Coupled Plasma Mass Spectrometry and high resolution γ-ray spectrometry for cold and radiolabelled nanoparticles, respectively. These preliminary results indicate that alterations to the nanoparticles’ properties introduced by proton bombardment can be controlled to a sufficient extent that their further use as radiotracers for biological investigations can be envisaged and elaborated.

Item Type:Article
Uncontrolled Keywords: Nanoparticles - Radiolabelling - Titanium dioxide - In vitro - Cell uptake - Nanomanufacturing - Nanomedicine
Subjects:Material Science > Functional and hybrid materials
Material Science > Nanofabrication processes and tools
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
Divisions:Faculty of Law, Arts and Social Sciences > School of Education
ID Code:9579
Deposited By:Lesley Tobin
Deposited On:27 Aug 2010 13:39
Last Modified:27 Aug 2010 13:39

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