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An integrated microfluidic chip for non-immunological determination of urinary albumin

Lin, Chun-Che and Tseng, Chin-Chung and Huang, Chao-June and Wang, Jung-Hao and Lee, Gwo-Bin (2010) An integrated microfluidic chip for non-immunological determination of urinary albumin. Biomedical Microdevices, 12 (5). pp. 887-896.

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Official URL: http://www.springerlink.com/content/n5m7154656v4r2...

Abstract

This study presents an integrated microfluidic chip for non-immunologically determining the concentrations of albumin in clinical urine samples. This microchip integrates membrane-type micromixers and a fan-shaped micropump capable of simultaneously and precisely delivering assay reagents to react with 6 urine samples in one single operation. The experimental results show that the coefficient of variation in the pumping rate is 2.42%. More importantly, using this unique chip design, only 2 electromagnetic valves are required for the actuation of the micromixer and the micropump. The working range of the proposed microchip is 2–200 mg/L of albumin, which covers the range of interest for the determination of microalbuminuria. Moreover, statistical analysis show that the results obtained by the proposed microchip are in good agreement with the conventional detection method, based on immunological assays. This simple, inexpensive and microchip-based platform presents a promising alternative to conventional immunological assays for measurement of urinary albumin, and is well suited for clinical applications.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Physics
Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:9498
Deposited By:JNCASR
Deposited On:22 Sep 2010 06:52
Last Modified:22 Sep 2010 06:52

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