Shim, Joon S. and Browne, Andrew W. and Ahn, Chong H. (2010) An on-chip whole blood/plasma separator with bead-packed microchannel on COC polymer. BIOMEDICAL MICRODEVICES, 12 (5). pp. 949-957. ISSN 1387-2176 (Print) 1572-8781 (Online)
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A disposable on-chip whole blood/plasma separator, which is able to separate plasma from whole human blood by capillary force through a bead-packed microchannel, has been designed, fabricated and characterized in this work. Various sizes of silica beads were slurry-packed through a microchannel using a bump structure which held beads in a defined region. The bead-packed microchannel induces a capillary force which allows plasma to move forward through the bead-packed column more rapidly than red blood cells (RBCs). The blood/plasma separator with bead-packed microchannel has successfully separated plasma from the whole blood without haemolysis of RBCs. The separation method developed in this work can be applied to various on-chip stationary filtrations of RBC for point-of-care clinical diagnostics.
|Subjects:||Biomedical Science > Nanobiotechnology|
|Deposited By:||M T V|
|Deposited On:||10 Aug 2010 16:13|
|Last Modified:||10 Aug 2010 16:13|
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