Schulte, P. A. and Murashov, V. and Zumwalde, R. and Kuempel, E. D. and Geraci, C. L. (2010) Occupational exposure limits for nanomaterials: state of the art. Journal of Nanoparticle Research, 12 (6). pp. 1971-1987.
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Assessing the need for and effectiveness of controlling airborne exposures to engineered nanomaterials in the workplace is difficult in the absence of occupational exposure limits (OELs). At present, there are practically no OELs specific to nanomaterials that have been adopted or promulgated by authoritative standards and guidance organizations. The vast heterogeneity of nanomaterials limits the number of specific OELs that are likely to be developed in the near future, but OELs could be developed more expeditiously for nanomaterials by applying dose–response data generated from animal studies for specific nanoparticles across categories of nanomaterials with similar properties and modes of action. This article reviews the history, context, and approaches for developing OELs for particles in general and nanoparticles in particular. Examples of approaches for developing OELs for titanium dioxide and carbon nanotubes are presented and interim OELs from various organizations for some nanomaterials are discussed. When adequate dose–response data are available in animals or humans, quantitative risk assessment methods can provide estimates of adverse health risk of nanomaterials in workers and, in conjunction with workplace exposure and control data, provide a basis for determining appropriate exposure limits. In the absence of adequate quantitative data, qualitative approaches to hazard assessment, exposure control, and safe work practices are prudent measures to reduce hazards in workers.
|Uncontrolled Keywords:||Nanomaterials - Regulation - Risk assessment - Occupational safety and health - Carbon nanotubes - Control banding|
|Subjects:||NanoSafety > Environment, health and safety aspects of nanotechnology|
|Deposited On:||02 Aug 2010 16:15|
|Last Modified:||23 Sep 2010 13:41|
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