Johnston, A. H. and Dalton, P. D. and Newman, T. A. (2010) Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure. Journal of Nanoparticle Research, 12 (6). pp. 1997-2001.
|PDF (Pre-print) - Other|
Official URL: http://www.springerlink.com/content/m87l52133324nu...
By incorporating ferrocene into the hydrophobic membrane of PEG-b-PCL polymersome nanoparticles it is possible to selectively visualize their core using Transmission Electron Microscopy (TEM). Two different sizes of ferrocene-loaded polymersomes with mean hydrodynamic diameters of approximately 40 and 90 nm were prepared. Image analysis of TEM pictures of these polymersomes found that the mean diameter of the core was 4–5 times smaller than the mean hydrodynamic diameter. The values obtained also allow the surface diameter and internal volume of the core to be calculated.
|Uncontrolled Keywords:||Nanoparticle - Characterization - Pharmacokinetics - Polymersomes - PEG - PCL - TEM - Biomedicine|
|Subjects:||Analytical Science > Microscopy and probe methods|
|Deposited On:||02 Aug 2010 12:47|
|Last Modified:||02 Aug 2010 12:47|
Repository Staff Only: item control page