Nano Archive

Preparation and Evaluation of Poly(Ethylene Glycol)Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A

Zhang, Yanhui and Li, Xinru and Zhou, Yanxia and Wang, Xiaoning and Fan, Yating and Huang, Yanqing and Liu, Yan (2010) Preparation and Evaluation of Poly(Ethylene Glycol)Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A. NANOSCALE RESEARCH LETTERS, 5 (6). pp. 917-925. ISSN 1931-7573 (Print) 1556-276X (Online)

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Official URL: http://www.springerlink.com/content/q4p34202760240...

Abstract

A series of monomethoxy poly(ethylene glycol)–poly(lactide) (mPEG–PLA) diblock copolymers were designed according to polymer–drug compatibility and synthesized, and mPEG–PLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narrow size distribution. The favorable stabilities of CyA-loaded polymeric micelles were observed in simulated gastric and intestinal fluids. The in vitro drug release investigation demonstrated that drug release was retarded by polymeric micelles. The enhanced intestinal absorption of CyA-loaded polymeric micelles, which was comparable to the commercial formulation of CyA (Sandimmun Neoral®), was found. These suggested that polymeric micelles might be an effective nanocarrier for solubilization of poorly soluble CyA and further improving oral absorption of the drug.

Item Type:Article
Subjects:Material Science > Bio materials
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:9289
Deposited By:M T V
Deposited On:03 Jun 2010 13:55
Last Modified:03 Jun 2010 13:55

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