Nano Archive

The Photodynamic Effect of Different Size ZnO Nanoparticles on Cancer Cell Proliferation In Vitro

Li, Jingyuan and Guo, Dadong and Wang, Xuemei and Wang, Huangping and Jiang, Hui and Chen, Baoan (2010) The Photodynamic Effect of Different Size ZnO Nanoparticles on Cancer Cell Proliferation In Vitro. NANOSCALE RESEARCH LETTERS, 5 (6). pp. 1063-1071. ISSN 1931-7573 (Print) 1556-276X (Online)

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Official URL: http://www.springerlink.com/content/533up71084pp95...

Abstract

Nanomaterials have widely been used in the field of biological and biomedicine, such as tissue imaging, diagnosis and cancer therapy. In this study, we explored the cytotoxicity and photodynamic effect of different-sized ZnO nanoparticles to target cells. Our observations demonstrated that ZnO nanoparticles exerted dose-dependent and time-dependent cytotoxicity for cancer cells like hepatocellular carcinoma SMMC-7721 cells in vitro. Meanwhile, it was observed that UV irradiation could enhance the suppression ability of ZnO nanoparticles on cancer cells proliferation, and these effects were in the size-dependent manner. Furthermore, when ZnO nanoparticles combined with daunorubicin, the related cytotoxicity of anticancer agents on cancer cells was evidently enhanced, suggesting that ZnO nanoparticles could play an important role in drug delivery. This may offer the possibility of the great potential and promising applications of the ZnO nanoparticles in clinical and biomedical areas like photodynamic cancer therapy and others.

Item Type:Article
Subjects:Material Science > Functional and hybrid materials
Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanomedicine
ID Code:9269
Deposited By:M T V
Deposited On:03 Jun 2010 15:01
Last Modified:03 Jun 2010 15:01

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