Nano Archive

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Zhang, Lingling and Jiang, Yunhong and Ding, Yulong and Daskalakis, Nikolaos and Jeuken, Lars and Povey, Malcolm and O’Neill, Alex J. and York, David W. (2010) Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli. Journal of Nanoparticle Research, 12 (5). pp. 1625-1636.

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Abstract

Aqueous suspensions containing 4.45 × 10−5 − 1.25 × 10−3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactions between other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the conditions of this study.

Item Type:Article
Uncontrolled Keywords:ZnO nanoparticles - E. coli - Toxicity - Antibacterial - Mechanism - Lipid vesicles - EHS
Subjects:Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:9261
Deposited By:SPI
Deposited On:08 Jun 2010 17:55
Last Modified:08 Jun 2010 17:55

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