Nano Archive

Biocompatibility of nanoactuators: stem cell growth on laser-generated nickel–titanium shape memory alloy nanoparticles

Barcikowski, Stephan and Hahn, Anne and Guggenheim, Merlin and Reimers, Kerstin and Ostendorf, Andreas (2010) Biocompatibility of nanoactuators: stem cell growth on laser-generated nickel–titanium shape memory alloy nanoparticles. Journal of Nanoparticle Research, 12 (5). pp. 1733-1742.

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Abstract

Nanoactuators made from nanoparticulate NiTi shape memory alloy show potential in the mechanical stimulation of bone tissue formation from stem cells. We demonstrate the fabrication of Ni, Ti, and NiTi shape memory alloy nanoparticles and their biocompatibility to human adipose-derived stem cells. The stoichiometry and phase transformation property of the bulk alloy is preserved during attrition by femtosecond laser ablation in liquid, giving access to colloidal nanoactuators. No adverse effect on cell growth and attachment is observed in proliferation assay and environmental electron scanning microscopy, making this material attractive for mechanical stimulation of stem cells.

Item Type:Article
Uncontrolled Keywords:Nanoparticles - Nanoactuators - Nickel - Titanium - Nitinol - Biocompatibility - Stem cell - Laser ablation - Bone tissue formation - Nanomedicine
Subjects:Biomedical Science > Nanotechnology for human health
NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:9235
Deposited By:SPI
Deposited On:08 Jun 2010 17:36
Last Modified:08 Jun 2010 17:36

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