Nano Archive

Development of monodispersed and functional magnetic polymeric liposomes via simple liposome method

Liang, Xiaofei and Wang, Hanjie and Jiang, Xinguo and Chang, Jin (2010) Development of monodispersed and functional magnetic polymeric liposomes via simple liposome method. Journal of Nanoparticle Research, 12 (5). pp. 1723-1732.

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Abstract

We are reporting a simple and rapid method to prepare superparamagnetic, controlled size, and monodispersed magnetic cationic polymeric liposomes (MCPL) by octadecyl quaternized carboxymethyl chitosan (OQCMC) and cholesterol. The whole process is only about 25 min with simple thin-film dispersion and solvent evaporation method. Hydrophilic magnetic nanoparticles (LM) and hydrophobic magnetic nanoparticles (BM) can be encapsulated into these cationic polymeric liposomes, simultaneously or respectively. A model hydrophobic drug indomethacin can be successfully filled in MCPL with high drug loading capacity 22%. MCPL encapsulating BM also showed strong DNA (pEGFP) binding ability. Drug-loaded MCPL have a long and controlled sustained release profile by changing the number of polymeric lipid layer. These functional MCPL nanospheres can be allowed to serve as ideal candidates for many biomedical applications.

Item Type:Article
Uncontrolled Keywords:Magnetic nanoparticles - Polymeric liposomes - Chitosan - Drug delivery - Nanomedicine
Subjects:Physical Science > Nanomagnetics
ID Code:9226
Deposited By:SPI
Deposited On:08 Jun 2010 17:26
Last Modified:08 Jun 2010 17:26

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