Nano Archive

Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery

Sakeena, M.H.F and Muthanna, F.A and Ghassan, Z.A. and Kanakal, M.M. and Elrashid, S.M. (2010) Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery. JOURNAL OF OLEO SCIENCE . ISSN 1345-8957

[img]
Preview
PDF
588Kb

Abstract

The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was prepared by spontaneous emulsification method. The droplets size was studied by laser scattering spectroscopy (Nanophox) and Transmission Electron Microscopy (TEM). Franz diffusion cells were used, to determine the drug release and drug transferred through methyl acetate cellulose membrane (artificial membrane). The results of droplets size analysis shows the droplets are in the range of nanoemulsion which is below than 500 rim. The in vitro release profile shows a sufficient percentage of drugs released through the methyl acetate cellulose membrane. This initial study showed that the nanoemulsion formulated using POEs has great potential for topical delivery of ketoprofen.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Material Science > Bio materials
ID Code:9213
Deposited By:CSMNT
Deposited On:19 May 2010 03:38
Last Modified:19 May 2010 03:38

Repository Staff Only: item control page