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Synthesis and characterization of gadolinium nanostructured materials with potential applications in magnetic resonance imaging, neutron-capture therapy and targeted drug delivery

Stefanakis Dimitriosand Ghanotakis, Demetrios (2010) Synthesis and characterization of gadolinium nanostructured materials with potential applications in magnetic resonance imaging, neutron-capture therapy and targeted drug delivery. Journal of Nanoparticle Research, 12 (4). pp. 1285-1297.

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Official URL: http://dx.doi.org/10.1007/s11051-010-9848-y

Abstract

Two Gadolinium nanostructured materials, Gd2(OH)5NO3 nanoparticles and Gd(OH)3 nanorods, were synthesized and extensively characterized by various techniques. In addition to the potential use of Gd2(OH)5NO3 in magnetic resonance imaging (MRI) and Neutron-capture therapy (NCT) application, it could also be used in targeted drug delivery. An antibiotic (nalidixic acid), two amino acids (aspartic and glutamic acid), a fatty acid and a surfactant (SDS) were intercalated in the nanoparticles. The surface of the nanoparticles was modified with folic acid in order to be capable of targeted delivery to folate receptor expressing sites, such as tumor human cells.

Item Type:Article
ID Code:9164
Deposited By:Prof. Alexey Ivanov
Deposited On:13 May 2010 12:54
Last Modified:13 May 2010 13:19

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