Nano Archive

High quality and tuneable silica shell-magnetic core nanoparticles

Vogt, Muhammet and Muhammed, Mamoun and Laurent, Sophie and Bridot, Jean-Luc and Müller, Robert (2010) High quality and tuneable silica shell-magnetic core nanoparticles. Journal of Nanoparticle Research, 12 (4). pp. 1137-1147.

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL:


Obtaining small (<50 nm), monodispersed, well-separated, single iron oxide core–silica (SiO2) shell nanoparticles for biomedical applications is still a challenge. Preferably, they are synthesised by inverse microemulsion method. However, substantial amount of aggregated and multicore core–shell nanoparticles is the undesired outcome of the method. In this study, we report on the production of less than 50 nm overall size, monodispersed, free of necking, single core iron oxide–SiO2 shell nanoparticles with tuneable shell thickness by a carefully optimized inverse microemulsion method. The high degree of control over the process is achieved by understanding the mechanism of core–shell nanoparticles formation. By varying the reaction time and precursor concentration, the thickness of silica layer on the core nanoparticles can be finely adjusted from 5 to 13 nm. Residual reactions during the workup were inhibited by a combination of pH control with shock freezing and ultracentrifuging. These high-quality tuneable core–shell nanocomposite particles exhibit superparamagnetic character and sufficiently high magnetization with great potential for biomedical applications (e.g. MRI, cell separation and magnetically driven drug delivery systems) either as-prepared or by additional surface modification for improved biocompatibility.

Item Type:Article
ID Code:9145
Deposited By:Prof. Alexey Ivanov
Deposited On:13 May 2010 12:53
Last Modified:13 May 2010 13:19

Repository Staff Only: item control page