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Effect of chain length and electrical charge on properties of ammonium-bearing bisphosphonate-coated superparamagnetic iron oxide nanoparticles: formulation and physicochemical studies

Karimi, Benoit and Hindré, François and Filmon, Robert and Greneche, Jean-Marc and Laurent, Sophie and Daou, T. and Begin-Colin, Sylvie and Le Jeune, Jean-Jacques (2010) Effect of chain length and electrical charge on properties of ammonium-bearing bisphosphonate-coated superparamagnetic iron oxide nanoparticles: formulation and physicochemical studies. Journal of Nanoparticle Research, 12 (4). pp. 1239-1248.

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Official URL: http://dx.doi.org/10.1007/s11051-009-9815-7

Abstract

Bisphosphonates BP molecules have shown to be efficient for coating superparamagnetic iron oxide particles. In order to clarify the respective roles of electrical charge and the length of the molecules, bisphosphonates with one or two ammonium moieties with an intermediate aliphatic group of 3, 5 or 7 carbons were synthesized and iron oxide nanoparticles coated. The evaluation on their iron core properties was made by transmission electron microscopy (TEM), nuclear magnetic relaxation dispersion (NMRD) profiles and Mössbauer spectra. The core size is close to 5 nm, with a global superparamagnetic behaviour modified by a paramagnetic Fe-based layer, probably due to surface crystal alteration. The hydrodynamic sizes increase slightly with aliphatic chain length (from 9.8 to 18.6 nm). The presence of one or two ammonium group(s) lowers the negative electrophoretic mobility up to bear zero values but reduces their colloidal stability. These BP-coated iron oxide nanoparticles are promising Magnetic Resonance Imaging (MRI) contrast agents.

Item Type:Article
ID Code:9143
Deposited By:Prof. Alexey Ivanov
Deposited On:13 May 2010 12:53
Last Modified:13 May 2010 13:19

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