Nano Archive

Metallophthalocyanine Based Carbon Paste Electrodes for the Determination of 2',3'-Dideoxyinosine

Ozoemena, Kenneth I. (2009) Metallophthalocyanine Based Carbon Paste Electrodes for the Determination of 2',3'-Dideoxyinosine. Electroanalysis, 21 (14). 1651 -1654.

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Abstract

Novel electrochemical sensors based on carbon paste impregnated with metallopthalocyanine (MPc, M¼Co, Fe) complexes, have been constructed for the assay of anti-HIV drug 2',3'-dideoxyinosine (didanosine, DDI). Both modified electrodes showed electrocatalytic activity towards the oxidation of dideoxyinosine in phosphate buffer pH 7.4 with a working concentration range of 10-7-10-4 mol/L and a detection limit of 10-7 mol/L magnitude order. The sensor proved to be highly reliable for the assay of the purity of DDI - raw material as well as for the uniformity content test of Videx tablets.

Item Type:Article
Subjects:Material Science > Nanochemistry
ID Code:9024
Deposited By:Mr Saleh Khamlich
Deposited On:15 Jul 2010 10:23
Last Modified:15 Jul 2010 10:23

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