Nano Archive

Localized Surface Plasmon Resonance Biosensing with Large Area of Gold Nanoholes Fabricated by Nanosphere Lithography

Xiang, Gansheng and Zhang, Nan and Zhou, Xiaodong (2010) Localized Surface Plasmon Resonance Biosensing with Large Area of Gold Nanoholes Fabricated by Nanosphere Lithography. Nanoscale Research Letters, 5 (5). pp. 818-822.

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Official URL: http://www.springerlink.com/content/3226013061226w...

Abstract

Localized surface plasmon resonance (LSPR) has been extensively studied as potential chemical and biological sensing platform due to its high sensitivity to local refractive index change induced by molecule adsorbate. Previous experiments have demonstrated the LSPR generated by gold nanoholes and its biosensing. Here, we realize large uniform area of nanoholes on scale of cm2 on glass substrate by nanosphere lithography which is essential for mass production. The morphology of the nanoholes is characterized using scanning electron microscope and atomic force microscope. The LSPR sensitivity of the nanoholes to local refractive index is measured to be 36 nm/RIU. However, the chip has demonstrated high sensitivity and specificity in biosensing: bovine serum albumin adsorption is detected with LSPR peak redshift of 27 nm, and biotin-streptavidin immunoassay renders a LSPR redshift of 11 nm. This work forms a foundation toward the cost-effective, high-throughput, reliable and robust chip-based LSPR biosensor.

Item Type:Article
Uncontrolled Keywords:Localized surface plasmon resonance (LSPR) - Nanosphere lithography (NSL) - Nanohole - Nanoparticles - Biosensing
Subjects:Physical Science > Nanophysics
Material Science > Tunnelling and microscopic phenomena
Material Science > Nanofabrication processes and tools
Analytical Science > Nanotechnology for sensing and actuating
ID Code:9010
Deposited By:Lesley Tobin
Deposited On:10 Aug 2010 11:21
Last Modified:10 Aug 2010 11:21

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