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Particle size of LDL is affected by the National Cholesterol Education Program (NCEP) step II diet in dyslipidaemic adolescents

Azadbakht, Leila and Mirmiran, Parvin and Hedayati, Mehdi and Esmaillzadeh, Ahmad and Shiva, Nilufar and Azizi, Fereidoun (2007) Particle size of LDL is affected by the National Cholesterol Education Program (NCEP) step II diet in dyslipidaemic adolescents. BRITISH JOURNAL OF NUTRITION, 98 (1). pp. 134-139.

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The objective was to determine the effects of the National Cholesterol Education Program (NCEP) step 11 diet on LDL and HDL particle size in dyslipidaemic adolescents. Forty-four dyslipidaemic adolescents, aged 10-18 years, participated in this case-control study. The control diet was a diet similar to what most Tehranian adolescents eat. NCEP step 11 diet was a diet with 30 % of energy as total fat, less than 7 % saturated fat, less than 200 mg cholesterol/d, less than 15 % of energy as MUFA and less than 10 % as PUFA. Lipoprotein particle size was the major outcome variable, which was measured after 3 months of intervention. Comparison was made by the repeated measurement ANOVA. The mean BMI was 26 center dot 3 (SD 4 center dot 2) kg/m(2). There were no significant changes in weight or physical activity in the two groups during the study. The NCEP diet resulted in higher reduction in total cholesterol (- 13 (SD 4) v. -2 (SD 0 center dot 3) mg/dl, P<0 center dot 001) and LDL (-9 (SD 2) v. 3 (SD 0 center dot 6) mg/dl, P<0 center dot 01), and higher increase in size of the LDL (1 center dot 7 (SD 0 center dot 4) v. 0 center dot 1 (SD 0 center dot 4) nanometer, P<0 center dot 001). HDL particle size did not change significantly. NCEP step 11 diet had a favourable effect on the LDL particle size. The related mechanism needs to be studied in future experimental designs.

Item Type:Article
Uncontrolled Keywords:National Cholesterol Education Program (NCEP) adolescents; LDL; lipoprotein particle size
Subjects:Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:888
Deposited On:05 Dec 2008 16:23
Last Modified:14 Aug 2009 12:24

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