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Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells

Yang, Jaemoon and Lim, Eun-Kyung and Lee, Eun-Sook and Suh, Jin-Suck and Haam, Seungjoo and Huh, Yong-Min (2010) Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells. Journal of Nanoparticle Research, 12 (4). pp. 1275-1283.

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Abstract

For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed ultrasensitive magnetoplex as a magnetic labeling agent composed of PEGylated MnFe2O4 nanocrystals (PMNCs) and polycationics (poly-l-lysine, PLL) for efficient labeling of the h-MSCs and monitoring of the transplanted h-MSCs for a long term. PMNCs were prepared by nanoemulsion methods composed of MnFe2O4 nanocrystals (MNCs) and amphiphilic polymers (mPEG–dodecanoic acid). The prepared PMNCs exhibited excellent biocompatibility and their polycationic complexes (PMNCs/PLL) demonstrated remarkable sensitivity compared with magnetic iron oxide nanoparticles (MION)/PLL or Ferumoxides/PLL. Furthermore, PMNCs demonstrated the potentials for novel diagnostic and therapeutic strategies with potential applications in various biomedical fields.

Item Type:Article
Uncontrolled Keywords:SUPERPARAMAGNETIC IRON-OXIDE; QUANTUM DOTS; NANOPARTICLES; PARTICLES; AGENTS
Subjects:Biomedical Science > Nanobiotechnology
Physical Science > Nanomagnetics
ID Code:8863
Deposited By:CSMNT
Deposited On:07 Jul 2010 12:21
Last Modified:25 Aug 2010 10:56

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