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Mixed micellar nanoparticle of amphotericin B and poly styrene-block-poly ethylene oxide reduces nephrotoxicity but retains antifungal activity

UNSPECIFIED (2007) Mixed micellar nanoparticle of amphotericin B and poly styrene-block-poly ethylene oxide reduces nephrotoxicity but retains antifungal activity. ARCHIVES OF PHARMACAL RESEARCH, 30 (10). pp. 1344-1349.

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Abstract

Mixed micellar nanoparticle consisting of amphotericin B (AmB) and poly styrene-block-poly ethylene oxide (PS-block-PEO)was prepared by high pressure homogenizer. Nephrotoxicity of the nanoparticle was investigated along with antifungal activity and self-aggregation status of the drug in the nanoparticle. Nephrotoxicity was markedly reduced when AmB was intravenously administered to rats as mixed micellar nanoparticle with PS-block-PEO in terms of transmission electron microscopy of tubular cells and creatinine clearance. Antifungal activity of AmB was not altered when the drug was in the form of mixed micellar nanoparticle compared to both conventional formulation and AmB micelle treated by same procedure without PS-block-PEO. Self-aggregation status of AmB molecules revealed monomeric in the mixed micellar nanoparticle with PS-block-PEO up to the therapeutic level of the drug (1-3 mM). The reduced nephrotoxicity of AmB in mixed micellar nanoparticle may be associated with the existence of the drug as monomeric form in the nanoparticle. Based on our result, formulation of AmB as mixed micellar nanoparticle with PS-block-PEO may be a promising alternative for the treatment of fungal diseases in patients who are at risk of renal dysfunction.

Item Type:Article
Uncontrolled Keywords:mixed micellar nanoparticle; amphotericin B; poly styrene-block-poly ethylene oxide; nephrotoxicity; self-aggregation
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for animal health
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:883
Deposited By:INVALID USER
Deposited On:05 Dec 2008 12:31
Last Modified:05 Dec 2008 12:31

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