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Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug

Cao, Shao-Wen and Zhu, Ying-Jie and Wu, Jin and Wang, Ke-Wei and Tang, Qi-Li (2010) Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug. Nanoscale Research Letters, 5 (4). pp. 781-785. ISSN 1931-7573 (Print) 1556-276X (Online)

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Official URL: http://www.springerlink.com/content/20924161270387...

Abstract

The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl2, (NH4)3PO4, and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.

Item Type:Article
Uncontrolled Keywords:Nanocomposite - P123 - Calcium phosphate - Hydrophobic drug - Sustained release
Subjects:Material Science > Functional and hybrid materials
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:8822
Deposited By:IoN
Deposited On:15 Jul 2010 10:17
Last Modified:15 Jul 2010 10:17

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