Nano Archive

Finite-Element Modelling of Biotransistors

Shinwari, M. W. and Deen, M. J. and Selvaganapathy, P. R. (2010) Finite-Element Modelling of Biotransistors. NANOSCALE RESEARCH LETTERS, 5 (3). pp. 494-500. ISSN 1931-7573 (Print) 1556-276X (Online)

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Current research efforts in biosensor design attempt to integrate biochemical assays with semiconductor substrates and microfluidic assemblies to realize fully integrated lab-on-chip devices. The DNA biotransistor (BioFET) is an example of such a device. The process of chemical modification of the FET and attachment of linker and probe molecules is a statistical process that can result in variations in the sensed signal between different BioFET cells in an array. In order to quantify these and other variations and assess their importance in the design, complete physical simulation of the device is necessary. Here, we perform a mean-field finite-element modelling of a short channel, two-dimensional BioFET device. We compare the results of this model with one-dimensional calculation results to show important differences, illustrating the importance of the molecular structure, placement and conformation of DNA in determining the output signal.

Item Type:Article
Subjects:Physical Science > Nanophysics
ID Code:8782
Deposited By:M T V
Deposited On:21 Apr 2010 15:05
Last Modified:21 Apr 2010 15:05

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