Purtov, K. V. and Petunin, A. I. and Burov, A. E. and Puzyr, A. P. and Bondar, V. S. (2010) Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances. NANOSCALE RESEARCH LETTERS, 5 (3). pp. 631-636. ISSN 1931-7573 (Print) 1556-276X (Online)
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Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgGI125 and RAM-nanodiamond-BSAI125 complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSAI125 complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibodyâantigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited By:||M T V|
|Deposited On:||21 Apr 2010 15:15|
|Last Modified:||21 Apr 2010 15:15|
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