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Chloroquine increases low-density lipoprotein removal from plasma in systemic lupus patients

Sachet, J. C. and Borba, E. F. and Bonfa, E and Vinagre, C. G. C. and Silva, V. M. and Maranhao, R. C. (2007) Chloroquine increases low-density lipoprotein removal from plasma in systemic lupus patients. LUPUS, 16 (4). pp. 273-278.

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Low-density lipoprotein (LDL) pathway in systemic lupus erythematosus (SLE) patients taking chloroquine diphosphate (CDP) was evaluated through the kinetic behavior of a radioactive cholesterol-rich nanoemulsion (LDE) that resembles the LDL lipidic structure. LDE was labeled with C-14-cholesteryl ester (C-14-CE), then IV injected in inactive female SLE patients: 10 taking CDP (CDP), 10 without therapy (NO THERAPY); and 10 normal subjects (CONTROL). Groups were age-matched and followed rigorous selection criteria of conditions that interfere in the lipid profile. Blood samples were collected in pre-established intervals after infusion for radioactivity measurement. Fasting lipoproteins were determined in the beginning of kinetic studies. Fractional clearance rate (FCR) of C-14-CE was significantly different in the three groups (P = 0.03). In fact, a greater FCR of C-14-CE was observed in CDP compared to NO THERAPY (0.076 +/- 0.037 versus 0.046 +/- 0.021 h(-1); P < 0.05) and to CONTROL (0.0516 +/- 0.0125 h(-1); P < 0.05). Accordingly, a significant lower total and LDL cholesterol were observed in CDP (156 +/- 16 and 88 +/- 16mg/dl) compared to NO THERAPY (174 +/- 15 and 108 +/- 17 mg/dl; P < 0.05) and to CONTROL (200 +/- 24 and 18 +/- 23 mg/dl; P < 0.05). In contrast, no difference in (FCR) of C-14-CE of NO THERAPY and CONTROL groups was observed. This is the first in vivo demonstration that LDE removal by LDL receptor from plasma is increased in SLE patients taking CDP with a consequent beneficial decrease in LDL-c levels.

Item Type:Article
Uncontrolled Keywords:atherosclerosis; chloroquine; dyslipoproteinemia; emulsions; lipoproteins; low-Density lipoprotein; systemic lupus erythematosus
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:874
Deposited On:05 Dec 2008 13:16
Last Modified:13 Feb 2009 09:02

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