Nano Archive

Viruses and virus-like protein assemblies - Chemically programmable nanoscale building blocks

Lee, L. Andrew and Niu, Zhongwei and Wang, Qian (2010) Viruses and virus-like protein assemblies - Chemically programmable nanoscale building blocks. Nano Research, 2 (5). pp. 349-364.


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Supramolecular proteins are generated using a limited set of twenty amino acids, but have distinctive functionalities which arise from the sequential arrangement of amino acids configured to exquisite three-dimensional structures. Viruses, virus-like particles, ferritins, enzyme complexes, cellular micro-compartments, and other supramolecular protein assemblies exemplify these systems, with their precise arrangements of tens to hundreds of molecules into highly organized scaffolds for nucleic acid packaging, metal storage, catalysis or sequestering reactions at the nanometer scale. These versatile protein systems, dubbed as bionanoparticles (BNPs), have attracted materials scientists to seek new opportunities with these pre-fabricated templates in a wide range of nanotechnology-related applications. Here, we focus on some of the key modification strategies that have been utilized, ranging from basic protein conjugation techniques to more novel strategies, to expand the functionalities of these multimeric protein assemblies. Ultimately, in combination with molecular cloning and sophisticated chemistries, these BNPs are being incorporated into many applications ranging from functional materials to novel biomedical drug designs.

Item Type:Article
Uncontrolled Keywords:Bionanoparticles - virus - bioconjugation - nanomaterials - bioimaging - drug delivery
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
ID Code:8724
Deposited By:Lesley Tobin
Deposited On:26 Mar 2010 12:02
Last Modified:26 Mar 2010 12:02

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