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Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line.

Bogdanović, Visnja and Stankov, Karmen and Icević, Ivana and Zikic, Dragan and Nikolić, Aleksandra and Solajić, Slavica and Djordjević, Aleksandar and Bogdanović, Gordana (2008) Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line. Journal of radiation research, 49 (3). pp. 321-7. ISSN 0449-3060 (Unpublished)

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/18285660

Abstract

Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pre-treatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismutase and glutathione peroxidase in irradiated K562 cells.

Item Type:Article
Uncontrolled Keywords:Fullerenol/ Radioprotection/ Oxidative stress/ K562 cell line
Subjects:Biomedical Science > Nanoscale biological processes
Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
ID Code:87
Deposited By:Lesley Tobin
Deposited On:29 Oct 2008 16:43
Last Modified:22 Jan 2009 15:15

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