Gajbhiye, Monali and Kesharwani, Jayendra and Ingle, Avinash and Gade, Aniket and Rai, Mahendra (2009) Fungus-mediated synthesis of silver nanoparticles and their activity against pathogenic fungi in combination with fluconazole. Nanomedicine: Nanotechnology, Biology and Medicine, 5 (4). 382 - 386.
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Official URL: http://www.sciencedirect.com/science/article/B7MDB...
Silver nanoparticles (Ag-NPs) are known to have inhibitory and bactericidal effects. Resistance of fungal infections has emerged in recent years and is a major health problem. Here, we report the extracellular biosynthesis of Ag-NPs using a common fungus, Alternaria alternata. Also in this study, these nanoparticles were evaluated for their part in increasing the antifungal activity of fluconazole against Phoma glomerata, Phoma herbarum, Fusarium semitectum, Trichoderma sp., and Candida albicans. The antifungal activity of fluconazole was enhanced against the test fungi in the presence of Ag-NPs. Fluconazole in combination with Ag-NPs showed the maximum inhibition against C. albicans, which was confirmed from the increase in fold area of inhibition, followed by P. glomerata and Trichoderma sp., which showed less increase in the fold area, whereas no significant enhancement of activity was found against P. herbarum and F. semitectum.
|Uncontrolled Keywords:||Alternaria alternata; Extracellular; Fluconazole; Pathogenic fungi; Silver nanoparticles|
|Subjects:||Material Science > Nanofabrication processes and tools|
Biomedical Science > Nanomedicine
|Deposited On:||22 Apr 2010 11:04|
|Last Modified:||22 Apr 2010 11:04|
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