Nano Archive

Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine

Wilson, Barnabas and Samanta, Malay K. and Santhi, Kumaraswamy and Kumar, K. P. Sampath and Ramasamy, Muthu and Suresh, Bhojraj (2010) Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine. Nanomedicine: Nanotechnology, Biology and Medicine, 6 (1). 144 - 152.

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Official URL: http://www.sciencedirect.com/science/article/B7MDB...

Abstract

Tacrine-loaded chitosan nanoparticles were prepared by spontaneous emulsification. The particle size and zeta potential was determined by scanning probe microscopy and Zetasizer, respectively. The prepared particles showed good drug-loading capacity. The in vitro release studies showed that after the initial burst, all the drug-loaded batches provided a continuous and slow release of the drug. Coating of nanoparticles with Polysorbate 80 slightly reduced the drug release from the nanoparticles. Release kinetics studies showed that the release of drug from nanoparticles was diffusion-controlled, and the mechanism of drug release was Fickian. The biodistribution of these particles after intravenous injection in rats showed that of nanoparticles coated with 1% Polysorbate 80 altered the biodistribution pattern of nanoparticles.

Item Type:Article
Uncontrolled Keywords:Tacrine; Chitosan nanoparticles; Alzheimer's disease; Biodistribution
Subjects:Biomedical Science > Nanomedicine
ID Code:8570
Deposited By:SPI
Deposited On:22 Apr 2010 11:01
Last Modified:22 Apr 2010 11:01

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