Li, Shuyi and Nguyen, Lynsa and Xiong, Hairong and Wang, Meiyao and Hu, Tom C.-C. and She, Jin-Xiong and Serkiz, Steven M. and Wicks, George G. and Dynan, William S. (2010) Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications. Nanomedicine: Nanotechnology, Biology and Medicine, 6 (1). 127 - 136.
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Official URL: http://www.sciencedirect.com/science/article/B7MDB...
Porous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the porous walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoporous walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications.
|Uncontrolled Keywords:||Drug delivery; Microsphere; Silica; Mesoporous; Controlled release; Single-chain antibody; Single-chain antibody variable fragment; Small interfering RNA|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||22 Apr 2010 10:59|
|Last Modified:||22 Apr 2010 10:59|
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