Nelson, Steve M. and Mahmoud, Tarek and II, Miles Beaux and Shapiro, Pamela and McIlroy, David N. and Stenkamp, Deborah L. (2010) Toxic and teratogenic silica nanowires in developing vertebrate embryos. Nanomedicine: Nanotechnology, Biology and Medicine, 6 (1). 93 - 102.
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Official URL: http://www.sciencedirect.com/science/article/B7MDB...
Abstract
Silica-based nanomaterials show promise for biomedical applications such as cell-selective drug delivery and bioimaging. They are easily functionalized, which allows for the conjugation or encapsulation of important biomolecules. Although recent in vitro studies suggested that silica-derived nanomaterials are nontoxic, in vivo studies of silica nanomaterial toxicity have not been performed. Using the embryonic zebrafish as a model system, we show that silica nanomaterials with aspect ratios greater than 1 are highly toxic (LD50 = 110 pg/g embryo) and cause embryo deformities, whereas silica nanomaterials with an aspect ratio of 1 are neither toxic nor teratogenic at the same concentrations. Silica nanowires also interfere with neurulation and disrupt expression of sonic hedgehog, which encodes a key midline signaling factor. Our results demonstrate the need for further testing of nanomaterials before they can be used as platforms for drug delivery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Nanowires; Silica; Teratogenic; Toxicity; Zebrafish |
| Subjects: | Risk > Environment, health and safety aspects of nanotechnology Biomedical Science > Nanomedicine |
| ID Code: | 8564 |
| Deposited By: | SPI |
| Deposited On: | 22 Apr 2010 10:57 |
| Last Modified: | 22 Apr 2010 10:57 |
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