Avadi, Mohammad Reza and Sadeghi, Assal Mir Mohammad and Mohammadpour, Nasser and Abedin, Saideh and Atyabi, Fatemeh and Dinarvand, Rassoul and Rafiee-Tehrani, Morteza (2010) Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method. Nanomedicine: Nanotechnology, Biology and Medicine, 6 (1). 58 - 63.
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Official URL: http://www.sciencedirect.com/science/article/B7MDB...
In the past decade, many strategies have been developed to enhance oral protein delivery. The aim of the current work was to develop a nanoparticulate system based on ionic gelation between chitosan and Arabic gum for loading of insulin. Various formulations were prepared using 23 factorial designs. The optimum association efficiency was obtained for formulations F2, F5, and F8. The release profile of insulin in phosphate buffer solutions (pH 6.5 and pH 7.2) is completely different than that in acidic medium (pH 1.2). Increased solubility of chitosan in acidic medium and better swelling of Arabic gum chains at pH >6.5 resulted in lower insulin release of nanoparticles at pH 6.5 in comparison with that of the other pH mediums. The values of the exponent n were 0.49 and 0.82 for formulations F8 and F5, respectively, indicating a non-Fickian transport. This suggests that release is possibly controlled by diffusion or relaxation of the polymer chains.
|Uncontrolled Keywords:||Arabic gum; Chitosan; Factorial design; Ionic gelation; Nanoparticle|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||22 Apr 2010 10:55|
|Last Modified:||22 Apr 2010 10:55|
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