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Simultaneous detection of dopamine, ascorbic acid, and uric acid at electrochemically pretreated carbon nanotube biosensors

Alwarappan, Subbiah and Liu, Guodong and Li, Chen-Zhong (2010) Simultaneous detection of dopamine, ascorbic acid, and uric acid at electrochemically pretreated carbon nanotube biosensors. Nanomedicine: Nanotechnology, Biology and Medicine, 6 (1). 52 - 57.

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Official URL: http://www.sciencedirect.com/science/article/B7MDB...

Abstract

In this work we have evaluated the performance of electrochemically pretreated single-walled carbon nanotubes (SWCNTs) toward the electrochemical detection of dopamine in the presence of ascorbic acid and uric acid at physiological pH. Results indicated that the electrochemically pretreated SWCNTs showed a selective and enhanced electroanalytical response with minimal electrode fouling toward the detection of dopamine than their untreated counterparts. The observed behavior is attributed to the negatively charged layer present on the SWCNTs originating from the rupture of the basal plane present on the end caps following electrochemical pretreatment. The rupture of basal plane is evident from surface Raman measurements. The negatively charged surface selectively allows the cationic dopamine toward the electrode and repels the anionic ascorbate and uric acid when they coexist in the same solution under physiological pH. A limit of detection of about 15 nM is obtained with these electrodes for the detection of dopamine in the presence of ascorbic acid and uric acid.

Item Type:Article
Uncontrolled Keywords:Nanobiosensor; Electrochemistry; Carbon nanotubes; Electrochemical activation; Dopamine; Neurotransmitter analysis
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanomedicine
ID Code:8558
Deposited By:SPI
Deposited On:22 Apr 2010 10:54
Last Modified:22 Apr 2010 10:54

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