Nano Archive

Self-assembled polymer nanostructures for delivery of anticancer therapeutics

Wiradharma, Nikken and Zhang, Ying and Venkataraman, Shrinivas and Hedrick, James L. and Yang, Yi Yan (2009) Self-assembled polymer nanostructures for delivery of anticancer therapeutics. Nano Today, 4 (4). 302 - 317.

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Official URL: http://www.sciencedirect.com/science/article/B82X8...

Abstract

Nanostructures self-assembled from amphiphilic functional copolymers have emerged as safe and efficient nanocarriers for delivery of anticancer therapeutics. The development of this class of nanostructures has advanced from basic spherical micelles for delivery of small molecular hydrophobic drugs to a more complex functional structure for more efficient delivery of a wide range of therapeutics including small molecular drugs, macromolecular proteins and genes. This review describes physiological barriers for delivery of therapeutics, summarizes various approaches to overcome these barriers, and discusses the challenges in the current approaches for cancer therapy and perspectives for future solutions.

Item Type:Article
Uncontrolled Keywords:Self-assembly; Polymer nanostructures; Drug delivery; Protein delivery; Gene delivery; Cancer therapy
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanomedicine
ID Code:8532
Deposited By:SPI
Deposited On:22 Apr 2010 10:46
Last Modified:22 Apr 2010 10:46

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