Nano Archive

Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes

Zaman, Noreen T. and Yang, Yi-Yan and Ying, Jackie Y. (2010) Stimuli-responsive polymers for the targeted delivery of paclitaxel to hepatocytes. Nano Today, 5 (1). 9 - 14.

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This study presents a targeted and stimuli-responsive drug delivery system to increase the therapeutic window of chemotherapeutic agents. Galactose was expressed on an amphiphilic, temperature- and pH-sensitive copolymer of N-isopropylacrylamide, N,N-dimethylacrylamide and 10-undecenoic acid. The polymer would self-assemble in aqueous medium, and was used to encapsulate paclitaxel. Various synthesis parameters were examined to achieve polymers that provide high drug loading and rapid release in a temperature- and pH-responsive manner. In the target hepatocyte cell line, the stimuli-responsive, galactose-expressing particles were significantly more toxic than the non-stimuli-responsive particles as well as the non-targeted particles.

Item Type:Article
Uncontrolled Keywords:Galactose-targeting; pH-sensitive; Thermosensitive; Paclitaxel; Hepatocytes
Subjects:Biomedical Science > Nanomedicine
ID Code:8508
Deposited By:SPI
Deposited On:22 Apr 2010 10:39
Last Modified:22 Apr 2010 10:39

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