Cappelli, Andrea and Galeazzi, Simone and Zanardi, Iacopo and Travagli, Valter and Anzini, Maurizio and Mendichi, Raniero and Petralito, Stefania and Memoli, Adriana and Paccagnini, Eugenio and Peris, Walter and Giordani, Antonio and Makovec, Francesco and Fresta, Massimo and Vomero, Salvatore (2010) A nanocomposite material formed by benzofulvene polymer nanoparticles loaded with a potent 5-HT3 receptor antagonist (CR3124). Journal of Nanoparticle Research, 12 (3). pp. 895-903.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Poly-BF3a, a new hydrophobic polymer obtained by spontaneous polymerization of 1-methylene-3-phenyl-1H-indene, was found to give nanoparticles characterized by favorable shape and dimensions. Poly-BF3a nanoparticles were loaded with CR3124, a potent 5HT3 antagonist, as a drug model by desolvation methods either in the absence or in the presence of polyethylene glycol (PEG1000) as a wetting agent. The SEM studies showed that the introduction of CR3124 into the preparation led to a variable degree of aggregationâcementation, which afforded a sort of nanocomposite material. In the absence of PEG1000, the drug molecule was found to stay in the amorphous state (DSC studies) when its percentage is not higher than 10% by weight. In vitro release experiments showed that the formation and stability of the dispersion as well as the drug release were remarkably affected by the presence of PEG1000, demonstrating its beneficial effect to the nanoparticle morphology and disaggregation.
|Deposited By:||Prof. Alexey Ivanov|
|Deposited On:||05 Dec 2010 20:33|
|Last Modified:||06 Dec 2010 11:26|
Repository Staff Only: item control page