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Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.

Takagi, Atsuya and Hirose, Akihiko and Nishimura, Tetsuji and Fukumori, Nobutaka and Ogata, Akio and Ohashi, Norio and Kitajima, Satoshi and Kanno, Jun (2008) Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. The Journal of toxicological sciences, 33 (1). pp. 105-16. ISSN 1880-3989

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Abstract

Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rod-shaped micrometer particles may share the carcinogenic mechanisms postulated for asbestos. To maintain sound activity of industrialization of nanomaterials, it would be prudent to implement strategies to keep good control of exposure to fibrous or rod-shaped carbon materials both in the workplace and in the future market until the biological/ carcinogenic properties, especially of their long-term biodurability, are fully assessed.

Item Type:Article
Subjects:Biomedical Science > Nanotechnology for animal health
Risk > Environment, health and safety aspects of nanotechnology
Biomedical Science > Nanotechnology for human health
ID Code:84
Deposited By:Lesley Tobin
Deposited On:29 Oct 2008 16:49
Last Modified:22 Jan 2009 16:41

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