Guo, Z. R. and Gu, C. R. and Fan, X. and Bian, Z. P. and Wu, H. F. and Yang, D. and Gu, N. and Zhang, J. N. (2009) Fabrication of Anti-human Cardiac Troponin I Immunogold Nanorods for Sensing Acute Myocardial Damage. Nanoscale Research Letters, 4 (12). pp. 1428-1433. ISSN 1931-7573 (Print) 1556-276X (Online)
Official URL: http://www.springerlink.com/content/dn22w0pt3v2761...
A facile, rapid, solution-phase method of detecting human cardiac troponin I for sensing myocardial damage has been described using gold nanorods-based biosensors. The sensing is demonstrated by the distinct change of the longitudinal surface plasmon resonance wavelength of the gold nanorods to specific antibody–antigen binding events. For a higher sensitivity, the aspect ratio of gold nanorods is increased up to ca 5.5 by simply adding small amount of HCl in seed-mediated growth solution. Experimental results show that the detecting limit of the present method is 10 ng/mL. Contrast tests reveal that these gold nanorods-based plasmonic biosensors hold much higher sensitivity than that of conventionally spherical gold nanoparticles.
|Subjects:||Physical Science > Nanophysics|
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
|Divisions:||Faculty of Engineering, Science and Mathematics > School of Physics|
Faculty of Engineering, Science and Mathematics > School of Chemistry
|Deposited On:||05 Jun 2010 09:09|
|Last Modified:||05 Jun 2010 09:09|
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