Nano Archive

Performance Evaluation on Effect of Pre-sonication on Nanoparticulates During Wet Nano-milling of Drugs

Radzuan, R. and Majeed, A. B. Abdul and Julianto, T and Hamzah, M. K and Hamzah, N. R and Bukhari, N. I (2009) Performance Evaluation on Effect of Pre-sonication on Nanoparticulates During Wet Nano-milling of Drugs. ICIEA: 2009 4TH IEEE CONFERENCE ON INDUSTRIAL ELECTRONICS AND APPLICATIONS, VOLS 1-6 .

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Abstract

Nano-sizing of drug particle size has been identified as a potentially effective method to increase solubility and hence drug effectiveness. By nanomilling, stable nano-scale particulates can be prepared which have improved physical properties. Nanoparticulates of poorly water-soluble drugs can be prepared by milling of drugs into nano range and achieve optimal stability condition. In this study, effect of pre-sonication followed by wet grinding was assessed on the particle sizes of griseofulvin and ketoconazole in dispersions containing surfactants. The sizes of drugs particulates were reduced to less than 200nm in size with a Polydispersity Index (PDI) below than 1.0 when pre-sonication and nanomilling were applied consecutively.

Item Type:Article
Subjects:Material Science > Nanochemistry
ID Code:8245
Deposited By:CSMNT
Deposited On:11 Feb 2010 08:05
Last Modified:11 Feb 2010 08:05

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