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Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles

Yudovin-Farber, Ira and Beyth, Nurit and Weiss, Ervin I. and Domb, Abraham J. (2010) Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles. Journal of Nanoparticle Research, 12 (2). pp. 591-603.

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Abstract

Quaternary ammonium polyethyleneimine (QA-PEI)-based nanoparticles were synthesized by crosslinking with dibromopentane followed by N-alkylation with various alkyl halides and further N-methylation with methyl iodide. Insoluble pyridinium-type particles were prepared by suspension polymerization of 4-vinyl pyridine followed by N-alkylation with alkyl halides. Polyamine-based nanoparticles embedded in restorative composite resin at 1% w/w were tested for antibacterial activity against Streptococcus mutans using direct contact test. Activity analysis revealed that the alkyl chain length of the QA-PEI nanoparticles plays a significant role in antibacterial activity of the reagent. The most potent compound was octyl-alkylated QA-PEI embedded in restorative composite resin at 1% w/w that totally inhibited S. mutans growth in 3-month-aged samples. This data indicates that restorative composite resin with antibacterial properties can be produced by the incorporation of QA-PEI nanoparticles.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Physics
Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:8217
Deposited By:JNCASR
Deposited On:10 Feb 2010 09:10
Last Modified:10 Feb 2010 09:10

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