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Experimental and numerical characterization of magnetophoretic separation for MEMS-based biosensor applications

Modak, Nipu and Kejriwal, Dinabandhu and Nandy, Krishanu and Datta, Amitava and Ganguly, Ranjan (2010) Experimental and numerical characterization of magnetophoretic separation for MEMS-based biosensor applications. BIOMEDICAL MICRODEVICES, 12 (1). pp. 23-34. ISSN 1387-2176 (Print) 1572-8781 (Online)

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Official URL: http://www.springerlink.com/content/n3j5647m443p04...

Abstract

Magnetophoretic isolation of biochemical and organic entities in a microfluidic environment is a popular tool for a wide range of bioMEMS applications, including biosensors. An experimental and numerical analysis of magnetophoretic capture of magnetic microspheres in a microfluidic channel under the influence of an external field is investigated. For a given microfluidic geometry, the operating conditions for marginal capture is found to be interrelated in such a manner that a unique critical capture parameter $<span class='mathrm'> Π <sub>textcrit}}} = łeft( I<sub>textcrit}}} texta}} right)}<sup>2</sup> } <span class='mathord'>łeft/ vphantom łeft( I<sub>textcrit}}} texta} right)<sup></sup>2</sub> textQ</span>η right. kern-νlldelimiterspace</sub> textQη </sub> </span><span class='mathrm'>, that is proportional to the ratio of the magnetic force to viscous force, can be identified. Influences of the flow rate, magnetic field and other parameters on the particle trajectories in the microfluidic channel are investigated both numerically and through bright-field imaging under a microscope. Like the event of critical capture, particle trajectories are also found to be guided by a similar parameter, π. Magnetophoretic capture efficiency of the device is also evaluated as a function of a nondimensional number </span><span class='mathrm'> Π <sup>*</sup> = χ textP}<sup>2</sup> texta}<sup>2</sup> } <span class='mathord'>łeft/ vphantom χ textP}<sup>2</sup> texta}<sup>2</sup> } łeft( textU}<sub>0</sub> η texth}<sup>5</sup> } right)}}}} right. kern-νlldelimiterspace} łeft( textU<sub></sub>0 η texth<sup></sup>5</span> right) </span>$, when both numerical and experimental results are found to agree reasonably well. Results of this investigation can be applied for the selection of the operating parameters and for prediction of device performance of practical microfluidic separators.

Item Type:Article
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanobiotechnology
Physical Science > Nanomagnetics
ID Code:8190
Deposited By:M T V
Deposited On:12 Feb 2010 14:01
Last Modified:12 Feb 2010 14:01

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