Takei, Kuniharu and Kawano, Takeshi and Kawashima, Takahiro and Sawada, Kazuaki and Kaneko, Hidekazu and Ishida, Makoto (2010) Microtube-based electrode arrays for low invasive extracellular recording with a high signal-to-noise ratio. BIOMEDICAL MICRODEVICES, 12 (1). pp. 41-48. ISSN 1387-2176 (Print) 1572-8781 (Online)
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Official URL: http://www.springerlink.com/content/r36286n1647u45...
We report on the development of a microtube electrode array as a neural interface device. To combine the desired properties for the neural interface device, such as low invasiveness with a small needle and a good signal-to-noise ratio in neural recordings, we applied the structure of a glass pipette electrode to each microtube electrode. The device was fabricated as sub-5-Î¼m-diameter out-of-plane silicon dioxide microtube arrays using silicon microneedle templates, which are grown by the selective vaporâliquidâsolid method. The microtubes had inner diameters of 1.9â6.4Â Âµm and a length of 25Â Âµm. Impedances ranged from 220Â kÎ© to 1.55Â MÎ©, which are less than those for conventional microneedles. In addition, the microtube electrodes had less signal attenuation than conventional microneedle electrodes. We confirmed that the effects of parasitic capacitances between neighboring microtubes and channels were sufficiently small using a test signal. Finally, neural responses evoked from a rat peripheral nerve were recorded in vivo using a microtube electrode to confirm that this type of electrode can be used for both electrophysiological measurements and as a neural interface device.
|Subjects:||Biomedical Science > Nanobiotechnology|
Physical Science > Nanoelectronics
|Deposited By:||M T V|
|Deposited On:||12 Feb 2010 14:05|
|Last Modified:||12 Feb 2010 14:05|
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