Nano Archive

Fabrication of three-dimensional microarray structures by controlling the thickness and elasticity of poly(dimethylsiloxane) membrane

Lee, Dae Ho and Park, Joong Yull and Lee, Eun-Joong and Choi, Yoon Young and Kwon, Gu Han and Kim, Beop-Min and Lee, Sang-Hoon (2010) Fabrication of three-dimensional microarray structures by controlling the thickness and elasticity of poly(dimethylsiloxane) membrane. BIOMEDICAL MICRODEVICES, 12 (1). pp. 49-54. ISSN 1387-2176 (Print) 1572-8781 (Online)

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Official URL: http://www.springerlink.com/content/x86u17x160161u...

Abstract

In this paper, we propose a method to construct three-dimensional curved microstructures with easy control of the size, position and shape, by exploiting the elasticity of poly(dimethylsiloxane) (PDMS) membranes and basic physics. For this end, we developed the method to handle thin PDMS membrane safely, and to replicate PDMS microstructure from the PDMS mold. Using this method, we demonstrated two potential applications: (1) the use of concave well for the formation of embryoid body (EB) to differentiate into neuronal cells, and (2) the fabrication of SU-8 and hydrogel microparticles having diverse curved shapes. The curved structures were successfully fabricated with simple process, and EBs were formed in the concave well and differentiated into the neuronal cells. Microparticles with diverse shapes were fabricated from a range of materials for potential use as drug carrier and pH responsive micro-actuator elements.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Material Science > Soft materials
ID Code:8187
Deposited By:M T V
Deposited On:12 Feb 2010 14:07
Last Modified:12 Feb 2010 14:07

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