Nano Archive

A low power, microvalve regulated architecture for drug delivery systems

Evans, Allan Thomas and Park, Jong M. and Chiravuri, Srinivas and Gianchandani, Yogesh B. (2010) A low power, microvalve regulated architecture for drug delivery systems. BIOMEDICAL MICRODEVICES, 12 (1). pp. 159-168. ISSN 1387-2176 (Print) 1572-8781 (Online)

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL:


This paper describes an actively-controlled architecture for drug delivery systems that offers high performance and volume efficiency through the use of micromachined components. The system uses a controlled valve to regulate dosing by throttling flow from a mechanically pressurized reservoir, thereby eliminating the need for a pump. To this end, the valve is fabricated from a glass wafer and silicon-on-insulator wafer for sensor integration. The valve draws a maximum power of 1.68 µW (averaged over time); with the existing packaging scheme, it has a volume of 2.475 cm3. The reservoirs are assembled by compressing polyethylene terephthalate polymer balloons with metal springs. The metal springs are fabricated from Elgiloy® using photochemical etching. The springs pressurize the contents of 37 mL chambers up to 15 kPa. The system is integrated with batteries and a control circuit board within a 113 cm3 metal casing. This system has been evaluated in different control modes to mimic clinical applications. Bolus deliveries of 1.5 mL have been regulated as well as continuous flows of 0.15 mL/day with accuracies of 3.22%. The results suggest that this device can be used in an implant to regulate intrathecal drug delivery.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
ID Code:8174
Deposited By:M T V
Deposited On:12 Feb 2010 14:32
Last Modified:12 Feb 2010 14:32

Repository Staff Only: item control page