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Fabrication of monodisperse, large-sized, functional biopolymeric microspheres using a low-cost and facile microfluidic device

Zhu, Liping and Li, Yaogang and Zhang, Qinghong and Wang, Hongzhi and Zhu, Meifang (2010) Fabrication of monodisperse, large-sized, functional biopolymeric microspheres using a low-cost and facile microfluidic device. BIOMEDICAL MICRODEVICES, 12 (1). pp. 169-177. ISSN 1387-2176 (Print) 1572-8781 (Online)

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Official URL: http://www.springerlink.com/content/m10g2280318560...

Abstract

We report a novel and facile method for fabricating coaxial microfluidic devices processing various dimensions at low cost, in which polypropylene hollow fibers or glass capillaries are used as the tip of the dispersed phase injection tube. With this coaxial microfluidic device, monodisperse biocompatible microspheres ranging from 300 to 800 μm were obtained by collecting oil-in-water or water-in-oil emulsions and solidifying the suspended microspheres. Microsphere size could be controlled by changing the tips or tuning the concentrations of the dispersed and continuous phases. By adding functional nanoparticles into the dispersed phase, it was demonstrated that fluorescent and magnetic microspheres can be fabricated easily using these microfluidic devices.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
ID Code:8173
Deposited By:M T V
Deposited On:12 Feb 2010 14:34
Last Modified:12 Feb 2010 14:34

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