Andelman, Tamar and Gordonov, Simon and Busto, Gabrielle and Moghe, Prabhas V. and Riman, Richard E. (2009) Synthesis and Cytotoxicity of Y2O3 Nanoparticles of Various Morphologies. Nanoscale Research Letters, 5 (2). pp. 263-273. ISSN 1931-7573 (Print) 1556-276X (Online)
Official URL: http://www.springerlink.com/content/f0276716206513...
As the field of nanotechnology continues to grow, evaluating the cytotoxicity of nanoparticles is important in furthering their application within biomedicine. Here, we report the synthesis, characterization, and cytotoxicity of nanoparticles of different morphologies of yttrium oxide, a promising material for biological imaging applications. Nanoparticles of spherical, rod-like, and platelet morphologies were synthesized via solvothermal and hydrothermal methods and characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), light scattering, surface area analysis, thermogravimetric analysis (TGA), and zeta potential measurements. Nanoparticles were then tested for cytotoxicity with human foreskin fibroblast (HFF) cells, with the goal of elucidating nanoparticle characteristics that influence cytotoxicity. Cellular response was different for the different morphologies, with spherical particles exhibiting no cytotoxicity to HFF cells, rod-like particles increasing cell proliferation, and platelet particles markedly cytotoxic. However, due to differences in the nanoparticle chemistry as determined through the characterization techniques, it is difficult to attribute the cytotoxicity responses to the particle morphology. Rather, the cytotoxicity of the platelet sample appears due to the stabilizing ligand, oleylamine, which was present at higher levels in this sample. This study demonstrates the importance of nanoparticle chemistry on inÂ vitro cytotoxicity, and highlights the general importance of thorough nanoparticle characterization as a prerequisite to understanding nanoparticle cytotoxicity.
|Uncontrolled Keywords:||Yttrium oxide - Y2O3 - Nanoparticle synthesis - Nanoparticle toxicity - Morphology control|
|Subjects:||Biomedical Science > Nanobiotechnology|
Risk > Environment, health and safety aspects of nanotechnology
Biomedical Science > Nanotechnology for human health
|Deposited By:||Lesley Tobin|
|Deposited On:||21 Jan 2010 15:14|
|Last Modified:||21 Jan 2010 15:14|
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