Chudasama, Bhupendra and Vala, Anjana K. and Andhariya, Nidhi and Upadhyay, R. V. and Mehta, R. V. (2009) Enhanced antibacterial activity of bifunctional Fe3O4-Ag core-shell nanostructures. Nano Research, 2 (12). pp. 955-965.
We describe a simple one-pot thermal decomposition method for the production of a stable colloidal suspension of narrowly dispersed superparamagnetic Fe3O4-Ag core-shell nanostructures. These biocompatible nanostructures are highly toxic to microorganisms. Antimicrobial activity studies were carried out on both Gram negative (Escherichia coli and Proteus vulgaris) and Gram positive (Bacillus megaterium and Staphylococcus aureus) bacterial strains. Efforts have been made to understand the underlying molecular mechanism of such antibacterial actions. The effect of the core-shell nanostructures on Gram negative strains was found to be better than that observed for silver nanoparticles. The minimum inhibitory concentration (MIC) values of these nanostructures were found to be considerably lower than those of commercially available antibiotics. We attribute this enhanced antibacterial effect of the nanostructures to their stability as a colloid in the medium, which modulates the phosphotyrosine profile of the bacterial proteins and arrests bacterial growth. We also demonstrate that these core-shell nanostructures can be removed from the medium by means of an external magnetic field which provides a mechanism to prevent uncontrolled waste disposal of these potentially hazardous nanostructures.
|Subjects:||Physical Science > Nanophysics|
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
|Divisions:||Faculty of Engineering, Science and Mathematics > School of Physics|
Faculty of Engineering, Science and Mathematics > School of Chemistry
|Deposited On:||11 Feb 2010 08:04|
|Last Modified:||16 Feb 2010 04:02|
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